Maximizing respiratory trial outcomes: From primary to exploratory measures

Quantitative evaluation of medical images plays an increasingly important role in research and clinical trials for drug development. Imaging-based outcomes reveal deeper insights into pulmonary diseases and allow for an earlier identification of abnormalities, with much better accuracy and precision, in comparison to traditional pulmonary function test methods.

Our advanced AI-powered chest CT analysis provide fast and robust quantitative assessment of all major lung pathologies.

In multi-site and longitudinal trials, where managing imaging variability is a major challenge, AI can help standardize analysis, ensuring consistent and reproducible assessments across different locations and time points.

By enhancing primary outcomes with objective, quantitative biomarkers, strengthening secondary measures with detailed structural and functional insights, and facilitating novel biomarker discovery, pharmaceutical companies can gain a strategic advantage in running more efficient, data-driven, and regulatory-aligned respiratory trials.

Robust CT outcome measures with Artificial Intelligence

Our AI-powered analysis of chest CT scans help pharmaceutical companies streamline clinical trials across different phases of drug development in a wide range of rare and common lung diseases, including COPD, bronchiectasis disease, asthma, ILD, Cystic Fibrosis and other.

Combining  advanced segmentation and quantification capabilities for analysing lung structures, airway and vessel dimensions and parenchymal density, we can provide detailed local assessment of emphysema, air trapping, bronchiectasis, mucus impaction, and other conditions.

The objective data generated by Artificial Intelligence, can help significantly improve trial efficiency and strengthen regulatory approval process. In Phase I and II trials, imaging can help detect early treatment signals and refine patient selection. In Phase III and IV, it may offer more precise efficacy assessments and support long-term disease monitoring.

Learn more on our LungQ technology platform and the measurement portfolio.

Supporting the full process towards optimal end results

  • CUSTOM TRIAL DESIGN

    Measurements precisely tailored to patient populations | Image acquisition requirements to ensure reproducible results | Effective inclusion criteria

  • OPTIMIZATION OF DATA REPRODUCIBILITY

    Normalization of incoming CT scans for reproducible quantitative assessment | AI Algorithms designed to handle data variation

  • ADVANCED IMAGE ANALYSIS LungQ™

    Wide range of exploratory and cleared measurements | Specialized Image Analysis Service for complex assessments | Pivotal markers approved for
    clinical use in Europe, UK, USA and Australia

  • DOUBLE QUALITY REVIEW

    ISO 13485 certified quality assurance process | 2-step quality review by human analysts

  • RESULTS INTERPRETATION

    Quantitative and 3D visual representation of outcomes | Imaging Expert Assistance for outcome interpretation

Clinical validation and scientific evidence

Thirona’s algorithms are being continuously validated across a wide range of lung diseases and patient populations, leveraging our strong network of partnerships with academia, academic hospitals, research organizations, and patient registries.

This ongoing evaluation includes comparisons with traditional assessment methods, multi-center studies, and real-world performance evaluations, ensuring high standards of accuracy, reproducibility, and clinical applicability in diverse settings.

For a detailed overview of our validation studies and published research, visit our Publications Page.

Partnering for the shortest path to the highest quality imaging endpoints​


Clinical trials often face unique challenges, from patient phenotyping and defining the best fit-for-purpose measurement, up to delivering robust evidence – it all needs to be done with no compromise to make sure trials are effective. ​

Our integral approach ensures fast and reliable delivery of precise imaging endpoints, while minimizing costs and time-to-market. ​

Full scope imaging service​

In partnership with Voiant, a clinical trial imaging solution provider, we offer a fully integrated service allowing to run clinical trials with imaging effectively, while minimizing risk of trial failure and saving on operational expenses. ​
With the unique benefit of our combined expertise in lung image analysis and clinical research, proven technology platform and well-guarded quality assurance process along the whole trial, we can guarantee robust results at any scale, with consistent output quality. One integral approach, one platform, one contractor for seamless operations and reliable execution.

Ready to apply AI image analysis to get better outcomes faster?


Let’s explore how we can work together!​