Evaluation of QCT metrics for COPD phenotyping in the COPDGene cohort

The study is designed to validate a range of AI-based quantitative lung CT (QCT) measures and to correlate the imaging-derived phenotypes with clinical outcomes to determine their potential for phenotyping of patients with COPD. ​The study also aims to explore the value of small airway analysis as a predictor of disease progression and exacerbations.

Project highlights

  • Preliminary results from 2,000 initial scans shared at ATS conference and ERS congress
  • Completion of large-scale analysis for the entire 10,000+ COPDGene participant (Phases 1–3)
  • Finalizing Phase 4 participant data to deliver definitive study outcomes

Contribution by Thirona

To analyze the study cohort, Thirona’s Bronchi-Arterial (LungQ® BA)​ and Mucus Plugs (LungQ® MP)​ metrics are used, providing detailed measurements of airway wall thickness, the total number and volume of mucus plugs, airway widening and narrowing on a segmental level.

Relevant Publications

July 2025

Airway mucus plugging in chronic bronchitis and the impact of Bronchial Rheoplasty

October 2024

Airway Thickening, Mucus Plugs and Eosinophilia in Bronchiectasis and Asthma

May 2025

Assessment of 10-year Progression in COPDGene Using Automated Measurements of Bronchus-Artery Ratios and Mucus Plugging

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