Thirona has a strong scientific heritage and has always placed an emphasis on research and clinical validation studies.

Find out more about our scientific contributions through this list of publications.

    • Bronchial Rheoplasty Reduces Mucus Plugging in Patients With Chronic Bronchitis | May 2024 | American Journal of Respiratory and Critical Care Medicine
    • Automated Analysis of Bronchus and Artery Dimensions on Chest Computed Tomography in Children With Primary Ciliary Dyskinesia | May 2024 | American Journal of Respiratory and Critical Care Medicine
    • Fully Automatic Assessment of Bronchus-Artery Dimensions and Ratios, Mucus Plugs, and Low Attenuation Regions in Cystic Fibrosis Patients Before and After Elexacaftor-Tezacaftor-Ivacaftor | May 2024 | American Journal of Respiratory and Critical Care Medicine
    • Cross-sectional Analysis of Automated Mucus Plug Quantification and Airway Wall Thickness in COPD Using AI-based Detection | May 2024 | American Journal of Respiratory and Critical Care Medicine
    • Fully Automated Mucus Plug Quantification on Chest CTs and Its Correlation With All-cause Mortality | May 2024 | American Journal of Respiratory and Critical Care Medicine
    • Fully Automatic Analysis of Bronchus-artery Dimensions and Ratios of 625 Chest CTS of Bronchiectasis Patients Participating in the EMBARC Registry | May 2024 | American Journal of Respiratory and Critical Care Medicine
    • Automated Quantification of Mucus Plugs in Smokers Using the LungQ Algorithm: A COPDGene Cohort Study | JAMA
    • AI-based quantification of pulmonary vascular changes aftr baloon pulmonaryh angioplasty: "The BP-AI study" | Pulmonary Vascular Research Institute Annual Congress
    • Prevalence of Pulmonary Vascular Abnormalities in Smokers With and Without COPD | May 2024 | American Journal of Respiratory and Critical Care Medicine
    • Azithromycin reduces bronchial wall thickening in infants with cystic fibrosis | Apr 2024 | Journal of Cystic Fibrosis
    • Dysanapsis is differentially related to lung function trajectories with distinct structural and functional patterns in COPD and variable risk for adverse outcomes | Jan 2024 | The Lancet
    • Baseline characteristics from a 3-year longitudinal study to phenotype subjects with COPD: the FOOTPRINTS study | Nov 2023 | Respiratory Research
    • The spectrum of structural lung changes in bronchiectasis: Analysis of 524 EMBARC CTs. | Oct 2023 | European Respiratory Journal
    • Higher pulmonary artery and vein volumes are associated with disease severity and mortality in smokers with and without COPD | Oct 2023 | European Respiratory Journal
    • CT-based diaphragm analysis to evaluate the diaphragm configuration with increasing COPD severity | Oct 2023 | European Respiratory Journal
    • CT-quantified pulmonary artery volume associates independently with higher mortality in smokers with and without COPD | Oct 2023 | European Respiratory Journal
    • Longitudinal changes in CT quantified pulmonary artery volume and interstitial abnormalities correlate with pulmonary function decline in IPF patients | Oct 2023 | European Respiratory Journal
    • The relationship between chest CT scoring, aetiology and severity of disease in Bronchiectasis: an EMBARC analysis | Oct 2023 | European Respiratory Journal
    • CT-quantified pulmonary artery volume associates independently with higher mortality in smokers with and without COPD | Oct 2023 | European Respiratory Journal
    • Automatic Analysis of Bronchus-Artery Dimensions to Diagnose and Monitor Airways Disease in Cystic Fibrosis | Sep 2023 | Thorax
    • Children with severe asthma have substantial structural airway changes on computed tomography | Aug 2023 | ERJ Open Research
    • The clinical impact of Lumacaftor-Ivacaftor on structural lung disease and lung function in children aged 6–11 with cystic fibrosis in a real-world setting | Aug 2023 | Respiratory Research
    • Automatic Bronchus and Artery Analysis on Chest Computed Tomography to Evaluate the Effect of Inhaled Hypertonic Saline in Children Aged 3-6 Years With Cystic Fibrosis in a Randomized Clinical Trial | May 2023 | Journal of Cystic Fibrosis
    • A Step Towards Early Detection of Pulmonary Hypertension on Non-Contrast Chest CT Scans Using Artificial Intelligence | May 2023 | American Thoracic Society
    • AI-based Model for the Automatized Quantification and Prognosis of IPF Patients | May 2023 | American Thoracic Society
    • Can AI-based Pulmonary Vascular Phenotyping on Chest-CT Detect Volume Shifts in Pulmonary Arterial and Venous Blood Volume in Operable and Non-operable Chronic Thromboembolic Pulmonary Hypertension? | May 2023 | American Thoracic Society
    • Effect of Lung Volume on Airway and Artery Analysis on Chest Computed Tomography in Chronic Obstructive Pulmonary Disease | May 2023 | American Thoracic Society
    • Artificial Intelligence-Based Analysis Differentiates PAH From PH Using Non-Contrast Chest CT Scans | May 2023 | American Thoracic Society
    • Development of a quantitative CT-based diaphragm tool in severe COPD patients treated with one-way endobronchial valves | May 2023 | American Thoracic Society
    • High-Resolution Computed Tomography-approximated Perfusion Is Comparable to Nuclear Perfusion Imaging in Severe Chronic Obstructive Pulmonary Disease | May 2023 | American Thoracic Society
    • Automated Measures of Airway-Artery Ratios Across Different GOLD Classes: A COPDGene Pilot Study | May 2023 | American Thoracic Society
    • Automatic and Manual Quantification of Small Airways Disease on Chest CT of Children With Severe Asthma | May 2023 | American Thoracic Society
    • Fully Automatic Quantitative Analysis of Airway-artery Dimensions and Ratios of Normal Chest CT Scans From Infancy Into Adulthood | May 2023 | American Thoracic Society
    • The Predictive Role of Artificial Intelligence-Based Chest CT Quantification in Patients with COVID-19 Pneumonia | Nov 2021 | Tomography
    • Sensitive automated airway-artery method to monitor progression of CF airway disease | Nov 2021 | European Respiratory Journal
    • Small airways targeted treatment with smart nebulizer technology could improve severe asthma in children: a retrospective analysis | Nov 2021 | Journal of Asthma
    • Determinants of Lung Fissure Completeness | Oct 2021 | American Journal of Respiratory and Critical Care Medicine
    • Virtual Reality and Artificial Intelligence for 3-dimensional Planning of Lung Segmentectomies | Jun 2021 | JTCVS Techniques
    • ‪Sex Differences in Airways Implications for Chronic Obstructive Pulmonary Disease‬ | May 2021 | American Thoracic Society
    • CT Quantification of Pulmonary Arteries, Airways and Parenchymal Fibrosis as Indicators of Disease Severity and Progression in Idiopathic Pulmonary Fibrosis | May 2021 | American Thoracic Society
    • Airway-Artery Ratios of Central and Peripheral Airways Quantified on CT as Independent Predictors of Airflow Obstruction in COPD | May 2021 | American Thoracic Society
    • Structural Airway Imaging Metrics are Differentially Associated with Persistent Chronic Bronchitis | Apr 2021 | Thorax
    • CT Quantification of Pulmonary Arteries, Airways and Parenchymal Fibrosis as Indicators of Disease Severity and Progression in Idiopathic Pulmonary Fibrosis | Mar 2021 | American Journal of Respiratory and Critical Care Medicine
    • Computed Tomography-based Airway Surface Area-to-Volume Ratio for Phenotyping Airway Remodeling in Chronic Obstructive Pulmonary Disease | Jan 2021 | American Journal of Respiratory and Critical Care Medicine
    • CT-based Airway Surface Area to Volume Ratio for Phenotyping Airway Remodeling in Chronic Obstructive Pulmonary Disease | Aug 2020 | American Journal of Respiratory and Critical Care Medicine
    • Automated Assessment of CO-RADS and Chest CT Severity Scores in Patients with Suspected COVID-19 Using Artificial Intelligence | Jul 2020 | Radiology
    • Evaluation of a deep learning system for the joint automated detection of diabetic retinopathy and age-related macular degeneration | Jun 2020 | Acta Ophthalmologica
    • Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: a prospective cohort study | May 2020 | BMC Pulmonary Medicine
    • Quantitative Airway Wall Thickening by Pi10 on Chest Imaging Is Increased in Symptomatic Military Deployers Compared to Controls, and Is Inversely Related to Forced Expiratory Volume in One Second | May 2020 | American Thoracic Society
    • COVID-19 on Chest Radiographs: A Multireader Evaluation of an Artificial Intelligence System | May 2020 | Radiology
    • Five-year Progression of Emphysema and Air Trapping at CT in Smokers with and Those without Chronic Obstructive Pulmonary Disease: Results from the COPDGene Study | Apr 2020 | Rad
    • Airway tapering: an objective image biomarker for bronchiectasis | Feb 2020 | European Radiology
    • Automated chest X-ray reading for tuberculosis in the Philippines to improve case detection: a cohort study | Jul 2019 | The International Journal of Tuberculosis and Lung Disease
    • Endobronchial valves for severe emphysema | Jun 2019 | European Respiratory Review
    • A Deep Learning Method to Estimate Conventional Dose Computed Tomography Scans from Reduced Dose Acquisitions: Effect on Emphysema Quantification | May 2019 | American Journal of Respiratory and Critical Care Medicine
    • A Novel Method for Quantification of Expiratory Airtrapping Independent of Expiration Level | May 2019 | American Journal of Respiratory and Critical Care Medicine
    • Genetic risk score has added value over initial clinical grading stage in predicting disease progression in age-related macular degeneration | Apr 2019 | Nature Scientific reports
    • Computer aided detection of tuberculosis on chest radiographs: An evaluation of the CAD4TB v6 system | Apr 2019 | ArXiv
    • Predictors of Response to Endobronchial Coil Therapy in Patients With Advanced Emphysema | Feb 2019 | Chest
    • Airway wall thickening on CT: Relation to smoking status and severity of COPD | Nov 2018 | Respiratory Medicine
    • Computer-assisted chest radiography reading for tuberculosis screening in people living with diabetes mellitus | Sep 2018 | International Journal of Tuberculosis and Lung Disease
    • Chartis Measurement of Collateral Ventilation: Conscious Sedation versus General Anesthesia - A Retrospective Comparison | Aug 2018 | Respiration
    • Evaluation of the diagnostic accuracy of Computer-Aided Detection of tuberculosis on Chest radiography among private sector patients in Pakistan | Jul 2018 | Nature Scientific Reports
    • Accuracy of an automated system for tuberculosis detection on chest radiographs in high-risk screening | May 2018 | International Journal of Tuberculosis and Lung Disease
    • Minimal important difference of target lobar volume reduction after endobronchial valve treatment for emphysema | Mar 2018 | Respirology
    • Disease Severity Dependence of the Longitudinal Association Between CT Lung Density and Lung Function in Smokers | Mar 2018 | Chest
    • Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression | Jan 2018 | Chest
    • Automated grading of fundus photographs to identify referable AMD for first-line eye care | Nov 2017 | JAMA Ophthalmology
    • Fast interactive segmentation of the pulmonary lobes from thoracic computed tomography data | May 2017 | Physics in Medicine and Biology
    • Automatic versus human reading of chest X-rays in the Zambia National Tuberculosis Prevalence Survey | Feb 2017 | International Journal of Tuberculosis and Lung Disease
    • Improving airway segmentation in computed tomography using leak detection with convolutional networks | Feb 2017 | Medical Image Analysis
    • Objective airway artery dimensions compared to CT scoring methods assessing structural cystic fibrosis lung disease | Jan 2017 | Journal of Cystic Fibrosis
    • Automatic Pulmonary Artery-Vein Separation and Classification in Computed Tomography Using Tree Partitioning and Peripheral Vessel Matching | Oct 2016 | IEEE Transactions on Medical Imaging
    • An automated tuberculosis screening strategy combining X-ray-based computer-aided detection and clinical information | Aug 2016 | Nature Scientific Reports
    • Follow-up of CT-derived airway wall thickness: Correcting for changes in inspiration level improves reliability | Jun 2016 | European Journal of Radiology
    • Genetic association analysis of drusen progression | Apr 2016 | Investigative Ophthalmology and Visual Science
    • Automatic Segmentation of Drusen and Exudates on Color Fundus Images using Generative Adversarial Networks | Mar 2016 | Biomedical Optics Express
    • Fast convolutional neural network training using selective data sampling: Application to hemorrhage detection in color fundus images | Feb 2016 | IEEE Transactions on Medical Imaging
    • Automatic differentiation of color fundus images containing drusen or exudates using a contextual spatial pyramid approach | Feb 2016 | Biomedical Optics Express
    • Normalizing computed tomography data reconstructed with different filter kernels: effect on emphysema quantification | May 2015 | European Radiology