Evaluation of QCT metrics for COPD phenotyping in the COPDGene cohort

The study is designed to validate a range of AI-based quantitative lung CT (QCT) measures and to correlate the imaging-derived phenotypes with clinical outcomes to determine their potential for phenotyping of patients with COPD. ​The study also aims to explore the value of small airway analysis as a predictor of disease progression and exacerbations.

Project highlights

  • Preliminary results from 2,000 initial scans shared at ATS conference 2025 and ERS congress 2025
  • Completion of large-scale analysis for the entire 10,000+ COPDGene participant (Phases 1–3)
  • Finalizing Phase 4 participant data to deliver definitive study outcomes

Contribution by Thirona

To analyze the study cohort, Thirona’s Bronchi-Arterial (LungQ® BA)​ and Mucus Plugs (LungQ® MP)​ metrics are used, providing detailed measurements of airway wall thickness, the total number and volume of mucus plugs, airway widening and narrowing on a segmental level.

Relevant Publications

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