The COPDGene Study is a large, 17-year multicenter observational study of over 10,000 smokers (with and without COPD across all GOLD stages) aiming to investigate the genetic and phenotypic factors of Chronic Obstructive Pulmonary Disease (COPD). The study is one of the largest studies to ever document the unique patterns of progression of COPD, its subtypes, and the epidemiologic, genetic and omic factors involved.
Novel Association: Identify smoking as a key risk factor for previously unsuspected interstitial lung abnormalities (ILA) on CT
Redefined Diagnosis: Introduce novelty to the field by redefining diagnostic criteria, and identifying new phenotypic, pathophysiologic, and genetic data concerning disease progression
Thirona is one of the research partners for the imaging arm of the study, providing AI-based quantitative CT scan analysis (emphysema quantification, airway measurements). Our robust algorithms used in COPDGene have been able to differentiate between subcategories of emphysema, identify early evidence of fibrosis, automatically trace the bronchi and pulmonary arteries to assess for morphologic changes, accurately measure air trapping.
